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CognitiveIn StockSubQ injection

Semax

Heptapeptide · ACTH(4–7) analogue · 7 amino acids

Half-life

~3-5min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

2–4 weeks

Refrigerate at 2-8C

Known For

Nootropic peptide. Synthetic analogue of ACTH (4-10). Enhances BDNF (brain-derived neurotrophic factor), improves memory, attention, and cognitive performance. Neuroprotective. Used clinically in Russia for stroke recovery and cognitive disorders.

Mechanism of Action

Synthetic ACTH(4-10) analog — neuroprotective + nootropic. Enhances BDNF, NGF expression. Approved in Russia for stroke, cognitive disorders.

Body vs. External Supply

🔴 Exogenous (replaces natural)

Brand / Trade Names

Semax® (approved in Russia/Ukraine) Manufacturer: Institute of Molecular Genetics (Russia) Not available as pharmaceutical outside Russia/CIS

Typical Research Dosage

Intranasal: 200-600mcg 2-3x daily. SubQ: 100-300mcg daily.

Vial Duration Guide

5mg vial at 600mcg/day = ~8 days. 10mg = ~17 days.

Recommended Vial Size

★ 5mg vials — RECOMMENDED At 600mcg/day, 5mg = ~8 days ✓. Same fragility as Selank. 5mg for freshness. 10mg = ~17 days ✓ also fine.

Time to Effects

EARLY: 15-30 minutes FULL: 2-4 weeks First dose: Cognitive stimulation within 15-30 minutes of intranasal use. Improved focus, motivation, mental clarity. Some compare it to a 'clean stimulant'. Week 1-2: BDNF upregulation. Improved memory, learning capacity, and attention span. Week 2-4: Neuroprotective benefits. Sustained cognitive enhancement. Immediate effects are noticeable from dose one. Cumulative BDNF benefits build over weeks. Minimum commitment: 2-4 weeks. Many cycle: 4 weeks on, 2-4 weeks off.

Contraindications & Do Not Combine

• Caution if history of seizures (BDNF upregulation may lower seizure threshold in susceptible individuals)

Common Side Effects

Nasal irritation, mild headache (rare), hair growth (anecdotal — BDNF/follicle stimulation). Very well tolerated.

Drug Interactions

MAOIs (theoretical, as Semax affects dopamine/serotonin), stimulants (additive)

Reversibility

Fully reversible — no dependence or withdrawal

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Ashmarin et al. (1995) Neurosci Behav Physiol 25:276-8 — Cognitive enhancement • Approved in Russia/Ukraine for stroke, cognitive disorders • NOT FDA APPROVED in USA/EU/Australia • ACTH(4-10) analog with additional amino acids • Multiple Russian clinical trials but limited English-language publications

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Nasal solution: 2-8°C, 14-30 days

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	2–4 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

Semax discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$55.00 per vial

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Quick Reference

Half-life	~3-5 minutes (intranasal — rapid CNS access)
Delivery	SubQ injection
Typical dose	200-600mcg
Storage (lyoph.)	2–8°C
Storage (recon.)	2–4 weeks
Endogenous?	Exogenous (replaces natural)
Suppression	None known
WADA	Not listed
FDA status	Not reviewed (Russian research)