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LongevityIn StockSubQ injection

Epithalon

Tetrapeptide · 4 amino acids · Pineal-derived sequence

Half-life

~30min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

room temp (stable)

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Synthetic version of Epithalamin (pineal gland extract). Activates telomerase, which lengthens telomeres — associated with cellular longevity. Also increases melatonin production, regulates circadian rhythm, and may have anti-cancer properties.

Mechanism of Action

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) — activates telomerase, potentially slowing telomere shortening. 30+ years Russian research (Khavinson). Anti-aging focus.

Body vs. External Supply

🔴 Exogenous (replaces natural)

Brand / Trade Names

Epithalamin® (original pineal extract, Russia) Epitalon/Epithalon (synthetic version) No Western pharmaceutical brand Research peptide only

Typical Research Dosage

2-5mg/day SubQ for 10-20 day courses. Repeat 2-3x per year.

Vial Duration Guide

10mg vial at 2mg/day = 5 days (need multiple for full course). 50mg vial = 10-25 days.

Recommended Vial Size

★ 50mg for full courses, 10mg for short At 2mg/day, 10mg = 5 days ✓. 50mg at 5mg/day = 10 days ✓, at 2mg/day = 25 days ✓. 50mg is better value for full 10-20 day courses.

Time to Effects

EARLY: During course FULL: Months post-course During 10-20 day course: Some report improved sleep quality (increased melatonin production). Subtle energy improvements. Week 2-4 post-course: Sleep quality stabilised. May feel 'rejuvenated'. Months post-course: Telomerase activation effects are measured in cellular markers, not subjective feelings. Benefits are cumulative over multiple courses (2-3x per year). This is a LONGEVITY investment. You won't 'feel' telomere lengthening. Measurable effects include improved sleep, possibly reduced biological age markers over time. Think years, not weeks.

Contraindications & Do Not Combine

No strict contraindications with other peptides on this list.

Common Side Effects

Very well tolerated in Russian studies. Injection site reaction (mild). No significant adverse events reported in 30+ years of use.

Drug Interactions

No significant known interactions

Reversibility

Fully reversible — no known suppression. Benefits may persist after treatment course.

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Khavinson et al. (2003) Bull Exp Biol Med 135:590-2 — Telomerase activation in human cells • Al-Dulaimi et al. (2025) Biogerontology 26(5):178 — Telomere elongation in cell lines (most recent) • Anisimov et al. (2001) Mech Ageing Dev 122:1437-48 — Lifespan extension in mice • Int J Mol Sci (2025) 26(6):2691 — Comprehensive review • NOT FDA APPROVED • Russian clinical use for 30+ years — limited Western replication • No Western randomized controlled human trials

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Lyophilized: room temp (stable). Reconstituted: 2-8°C, 14-21 days.

State	Condition	Duration
Lyophilised (sealed)	room temp (stable)	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

Epithalon discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$40.00 per vial

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Quick Reference

Half-life	~30 minutes to hours (estimated)
Delivery	SubQ injection
Typical dose	2-5mg/day
Storage (lyoph.)	room temp (stable)
Storage (recon.)	4–6 weeks
Endogenous?	Exogenous (replaces natural)
Suppression	None
WADA	Not listed
FDA status	Not reviewed (Russian research)