Longevity

Epithalon

Tetrapeptide · 4 amino acids · Pineal-derived sequence

FDA · NOT REVIEWED (RUSSIAN RESEARCH)

Half-life

~30 minutes

Very short

minsdays

Route

SubQ injection

Evidence

Early human data

Risk

Standard

Overview

Known for

Synthetic version of Epithalamin (pineal gland extract). Activates telomerase, which lengthens telomeres — associated with cellular longevity. Also increases melatonin production, regulates circadian rhythm, and may have anti-cancer properties.

Mechanism

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) — activates telomerase, potentially slowing telomere shortening. 30+ years Russian research (Khavinson). Anti-aging focus.

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Secondary
Supply & nature
ExogenousExogenous
FDA category
Not reviewed (Russian research)

Evidence & standing

Evidence base
Early human data
Risk level
Standard
Best studies
7 references
  • Khavinson et al. (2003) Bull Exp Biol Med 135:590-2 — Telomerase activation in human cells
  • Al-Dulaimi et al. (2025) Biogerontology 26(5):178 — Telomere elongation in cell lines (most recent)
  • Anisimov et al. (2001) Mech Ageing Dev 122:1437-48 — Lifespan extension in mice
  • Int J Mol Sci (2025) 26(6):2691 — Comprehensive review
  • NOT FDA APPROVED
  • Russian clinical use for 30+ years — limited Western replication
  • No Western randomized controlled human trials

Dosage & protocol

Typical dose
2-5mg/day
Research range
5–10 mg
Cycle
10-day course / 6 months off
Onset
10 days first effects
Full effect
90 days
Half-life
~30min
~30 minutes to hours (estimated)
Protocol

2-5mg/day SubQ for 10-20 day courses. Repeat 2-3x per year.

Time to effects

EARLY: During course

FULL: Months post-course

During 10-20 day course: Some report improved sleep quality (increased melatonin production). Subtle energy improvements.

Week 2-4 post-course: Sleep quality stabilised. May feel 'rejuvenated'.

Months post-course: Telomerase activation effects are measured in cellular markers, not subjective feelings. Benefits are cumulative over multiple courses (2-3x per year).

This is a LONGEVITY investment. You won't 'feel' telomere lengthening. Measurable effects include improved sleep, possibly reduced biological age markers over time. Think years, not weeks.

Recommended vial
  • 50mg for full courses, 10mg for short

At 2mg/day, 10mg = 5 days ✓. 50mg at 5mg/day = 10 days ✓, at 2mg/day = 25 days ✓. 50mg is better value for full 10-20 day courses.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Fully Reversible
Side effects

Very well tolerated in Russian studies. Injection site reaction (mild). No significant adverse events reported in 30+ years of use.

Interactions

No significant known interactions

Handle with research caution

No strict contraindications with other peptides on this list.

Storage & handling

Lyophilised
12–24 months
room temp (stable)
Reconstituted
4–6 weeks
2–8°C

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