Selank

Half-life

~4 minutes

Very short

minsdays

Route

SubQ injection

Evidence

Approved therapeutic

Risk

Standard

Overview

Known for

Nootropic and anxiolytic peptide. Synthetic analogue of the immunomodulatory peptide tuftsin. Reduces anxiety without sedation, improves memory and focus, and modulates immune function. Popular in Russian clinical practice.

Mechanism

Synthetic analog of tuftsin (immune peptide). Anxiolytic (anti-anxiety) + nootropic (cognitive enhancement). Modulates GABA, serotonin, dopamine. Approved in Russia.

Key facts

Format

Lyophilized powder

Mechanism targets

Classification

Authoritative

Supply & nature

ExogenousExogenous

FDA category

Not reviewed (Russian research)

Evidence & standing

Evidence base

Approved therapeutic

Risk level

Standard

Best studies

5 references

Zozulya et al. (2001) Bull Exp Biol Med 131:564-6 — Anxiolytic effects
Seredenin et al. (2002) Bull Exp Biol Med 133:143-5
Approved in Russia as anxiolytic nasal spray
NOT FDA APPROVED in USA/EU/Australia
Modified tuftsin analog — limited Western clinical data

Dosage & protocol

Typical dose

200-400mcg

Research range

250–500 µg

Cycle

2 weeks on / 2 weeks off

Onset

0 days first effects

Full effect

21 days

Half-life

~3-5min

~3-5 minutes (intranasal — acts rapidly on brain)

Protocol

Intranasal: 200-400mcg 2-3x daily. SubQ: 100-300mcg daily.

Time to effects

EARLY: 15-30 minutes

FULL: 2-4 weeks

First dose: Anxiolytic effects can be felt within 15-30 minutes of intranasal administration. Subtle calm, improved focus without sedation.

Week 1-2: Anxiety reduction becomes more consistent. Improved stress tolerance. Better focus and mental clarity.

Week 2-4: Full nootropic and anxiolytic effect. Immune modulation benefits. Stabilised mood.

One of the faster-acting nootropic peptides. Minimum commitment: 2-4 weeks for sustained cognitive benefits. Many feel the anti-anxiety effect from dose one.

Recommended vial

5mg vials — RECOMMENDED

At 400mcg/day, 5mg = ~12.5 days ✓. Selank is fragile (2-4 wk shelf life). 5mg ensures maximum potency. 10mg = 25 days — borderline.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility

Fully Reversible

Side effects

Nasal irritation, fatigue (rare), slight sedation at higher doses. Generally very well tolerated.

Interactions

Benzodiazepines (additive but different mechanism — not cross-tolerant), SSRIs, alcohol

Handle with research caution

No strict contraindications with other peptides on this list.

Storage & handling

Lyophilised

12–24 months

room temp

Reconstituted

2–4 weeks

2–8°C

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