Home / Catalogue/ Longevity/ MOTS-C

LongevityMetabolicIn StockSubQ injection

MOTS-C

Mitochondrial peptide · 16 amino acids · mtDNA-encoded

Half-life

~2-4h

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Mitochondria-derived peptide. Regulates metabolic homeostasis, improves insulin sensitivity, enhances exercise capacity, and promotes fat oxidation. Sometimes called 'exercise in a peptide'. Also has anti-aging properties.

Mechanism of Action

Mitochondrial-derived peptide (encoded by mtDNA) — "exercise mimetic." Activates AMPK, improves glucose metabolism, enhances physical performance. Endogenous (body makes it).

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No pharmaceutical brand Research peptide only Discovered 2015 (Lee et al.)

Typical Research Dosage

5-10mg SubQ 3-5x per week. Some protocols use 10mg daily for metabolic conditions.

Vial Duration Guide

10mg vial at 5mg 3x/wk = ~0.7 weeks. 40mg at 5mg 3x/wk = ~2.7 weeks.

Recommended Vial Size

★ 20mg or 30mg vials At 5mg 3x/wk, 10mg = ~4.7 days, 20mg = ~9 days, 30mg = ~14 days ✓. All sizes work. 20-30mg for less frequent reconstitution.

Time to Effects

EARLY: 1-2 weeks FULL: 4-8 weeks Week 1-2: Improved exercise performance and endurance. Better glucose metabolism. Some feel more energetic. Week 2-4: Enhanced fat oxidation during exercise. Improved insulin sensitivity measurable on blood work. Week 4-8: Significant metabolic improvements. Body composition shift. Exercise capacity enhanced. Effects on exercise performance are often noticed quite quickly. Minimum commitment: 4 weeks. Best assessed with blood work (fasting glucose, HbA1c).

Contraindications & Do Not Combine

No strict contraindications with other peptides on this list.

Common Side Effects

Limited data: injection site reaction, mild GI (reported). No significant adverse events in limited human studies.

Drug Interactions

Metformin (similar AMPK mechanism — potentially additive), other AMPK activators

Reversibility

🟡 Fully reversible — supplementing naturally produced mitochondrial peptide

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Lee et al. (2015) Cell Metab 21:443-54 — Discovery paper, exercise mimetic • Kim et al. (2018) J Am Geriatr Soc — Aging and physical capacity • Mitochondrial-derived peptide — endogenously produced • NOT FDA APPROVED • Limited human data — primarily preclinical/observational

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 14-21 days

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

MOTS-C discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$70.00 per vial

Submit Your Test Results →

Quick Reference

Half-life	~Hours (estimated — limited PK data)
Delivery	SubQ injection
Typical dose	5-10mg
Storage (lyoph.)	2–8°C
Storage (recon.)	4–6 weeks
Endogenous?	Natural/Topping Up
Suppression	None known
WADA	Not listed — investigational
FDA status	Preclinical only