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LongevityMetabolicIn StockSubQ injection

NAD+ (Injectable)

Dinucleotide coenzyme · Redox cofactor · Synthetic

Half-life

~45min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

room temp

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Nicotinamide Adenine Dinucleotide. Essential coenzyme for cellular energy production, DNA repair, and sirtuin activation. Declines significantly with age. Injectable NAD+ bypasses digestive degradation. Improves energy, mental clarity, and may slow aging.

Mechanism of Action

Coenzyme in every cell — critical for energy metabolism, DNA repair, sirtuin activation. Declines ~50% from age 20 to 50. IV bypasses poor oral bioavailability.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No brand for injectable NAD+ Related oral precursors: Tru Niagen® (NR — ChromaDex) Elysium Basis® (NR) Alive by Science (NMN, liposomal NAD+)

Typical Research Dosage

IV: 250-500mg per session (clinical setting). SubQ/IM: 50-100mg daily or 2-3x per week.

Vial Duration Guide

500mg vial at 100mg/day = 5 days. 1000mg = 10 days.

Recommended Vial Size

★ 500mg vials At 100mg/day, 100mg = 1 day (impractical). 500mg = 5 days ✓. 1000mg = 10 days ✓. 500mg is practical minimum.

Time to Effects

EARLY: Immediately-24hrs FULL: 2-4 weeks IV infusion: Effects felt DURING the session — increased energy, mental clarity, sometimes euphoria. Also potential nausea, chest tightness (infuse slowly). SubQ/IM: Within 24-48 hours — improved energy, mental clarity, reduced brain fog. Week 1-2: Significantly improved energy levels. Better focus. Reduced fatigue. Week 2-4: Cumulative cellular benefits. Improved exercise recovery. Enhanced cognitive function. One of the fastest 'felt' peptides. Many report immediate effects from IV and within days from SubQ. Minimum commitment: 2-4 weeks for sustained benefits.

Contraindications & Do Not Combine

No strict contraindications with other peptides on this list.

Common Side Effects

IV: chest tightness/pressure (30-40%, dose-rate dependent), nausea, flushing, headache, cramping. SubQ: injection site discomfort.

Drug Interactions

Alcohol (depletes NAD+), chemotherapy drugs (PARP inhibitors interact — olaparib etc.), medications metabolized by NAD+-dependent enzymes

Reversibility

🟡 Fully reversible — supplementing naturally declining molecule. No suppression of endogenous production.

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Yoshino et al. (2018) Cell Metab 27:529-47 — NAD+ metabolism review • Rajman et al. (2018) Cell Metab 27:529-47 — NAD+ and healthspan • Mills et al. (2016) Cell Metab 24:795-806 — NMN in aging mice • IV NAD+ lacks large-scale human RCTs • NOT FDA APPROVED as injectable therapeutic • Oral precursors (NR, NMN) more commonly studied in humans

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

IV solution: 2-8°C, use within hours of preparation. SubQ: 2-8°C. Oral: room temp.

State	Condition	Duration
Lyophilised (sealed)	room temp	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

NAD+ (Injectable) discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

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$40.00 per vial

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Quick Reference

Half-life	~45 minutes (IV NAD+ cleared rapidly) \| SubQ: variable
Delivery	SubQ injection
Typical dose	250-500mg
Storage (lyoph.)	room temp
Storage (recon.)	4–6 weeks
Endogenous?	Natural/Topping Up
Suppression	None
WADA	Not listed
FDA status	Not reviewed (supplement)