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HMG (Human Menopausal Gonadotropin)

Glycoprotein · FSH/LH mixture · Urinary-derived

Half-life

~24–37h

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

1–2 weeks

Refrigerate at 2-8C

Known For

Contains both FSH and LH. Used in fertility treatments. Directly stimulates ovaries (women) or testes (men) for sperm/egg production. More complete gonadotropin profile than HCG alone.

Mechanism of Action

Purified FSH + LH from postmenopausal urine. Stimulates follicle development (FSH) and ovulation/testosterone production (LH). Gold standard for fertility.

Body vs. External Supply

🔴 Exogenous (replaces natural)

Brand / Trade Names

Menopur® (Ferring) Repronex® (discontinued) Menogon® (Ferring) Merional® (IBSA)

Typical Research Dosage

75-150 IU IM 2-3x per week. Used under medical supervision for fertility.

Vial Duration Guide

75 IU vial = single use at standard dose.

Recommended Vial Size

★ 75 IU (only size) Single-use vial at standard dose. Use immediately. No shelf life concern.

Time to Effects

EARLY: 2-4 weeks FULL: 3-6 months Week 2-4: FSH/LH levels rise. Testosterone production increasing. Month 1-2: Hormonal improvements noticeable — energy, mood, libido. Month 3-4: Semen analysis shows improved sperm count and motility (one full spermatogenesis cycle = 74 days). Month 4-6: Full fertility benefit realised. For fertility: MINIMUM 3 months commitment (one sperm cycle). Many fertility clinics run 6-month protocols. Semen analysis at baseline, 3 months, and 6 months.

Contraindications & Do Not Combine

• Caution combining with HCG (overlapping gonadotropin stimulation — combined doses may overstimulate) • Females: risk of ovarian hyperstimulation syndrome (OHSS) — medical supervision required

Common Side Effects

Injection site pain, OHSS (women — serious: 1-5%), multiple pregnancy risk (20-30% twins), headache, bloating

Drug Interactions

GnRH agonists/antagonists (protocol-dependent), clomiphene, aromatase inhibitors

Reversibility

Reversible — axis returns to baseline

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• FDA Approved: Menopur, Repronex for infertility • Contains both FSH + LH activity (urinary-derived) • Standard fertility treatment for 40+ years • Lunenfeld (2004) Reprod Biomed Online 9:680-91 — Historical review • Gold standard for gonadotropin replacement in hypogonadotropic hypogonadism

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Refrigerate 2-8°C. Reconstituted: use promptly.

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	1–2 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

HMG (Human Menopausal Gonadotropin) discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

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$65.00 per vial

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Quick Reference

Half-life	FSH component: ~37hrs \| LH component: ~24hrs
Delivery	SubQ injection
Typical dose	75-150 IU
Storage (lyoph.)	2–8°C
Storage (recon.)	1–2 weeks
Endogenous?	Exogenous (replaces natural)
Suppression	None (stimulates)
WADA	Prohibited (S2)
FDA status	Approved (Menopur)