HealingImmune

KPV

Tripeptide · Alpha-MSH C-terminal fragment · 3 amino acids

FDA · PRECLINICAL ONLY

Half-life

~1.5 hours

Short

minsdays

Route

SubQ injection

Evidence

Preclinical only

Risk

Standard

Overview

Known for

Anti-inflammatory tripeptide derived from alpha-MSH. Blocks NF-kB pathway, reduces TNF-alpha and IL-6. Particularly beneficial for gut inflammation (IBD, colitis), skin inflammation, and general immune modulation. No tanning effect (unlike full alpha-MSH).

Mechanism

Tripeptide derived from alpha-MSH — potent anti-inflammatory. Downregulates NF-κB pathway. Used for gut inflammation (IBD/IBS), skin inflammation.

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Secondary
Supply & nature
Natural / Topping UpNatural
FDA category
Preclinical only

Evidence & standing

Evidence base
Preclinical only
Risk level
Standard
Best studies
5 references
  • Brzoska et al. (1999) FEBS Lett 461:137-42 — Anti-inflammatory tripeptide from alpha-MSH
  • Kannengiesser et al. (2008) PLoS One 3:e3624 — Colitis model
  • Derived from C-terminal of alpha-MSH
  • NOT FDA APPROVED
  • Primarily preclinical data (gut inflammation models)

Dosage & protocol

Typical dose
200-500mcg/day
Research range
0.5–1 mg
Cycle
4 weeks on / 2 weeks off
Onset
10 days first effects
Full effect
42 days
Half-life
~1-2h
~Hours (estimated — limited PK data)
Protocol

200-500mcg/day SubQ or oral. Some protocols use up to 1mg/day for active gut inflammation.

Time to effects

EARLY: 1-2 weeks

FULL: 4-8 weeks

Week 1-2: Anti-inflammatory effects beginning. If used for gut issues (IBD, IBS), may notice reduced bloating, discomfort, and improved digestion.

Week 2-4: Significant inflammation reduction. Gut barrier function improving. Skin inflammation (if present) improving.

Week 4-8: Full anti-inflammatory benefit. Gut healing substantial. Skin conditions improved.

Gut-related improvements are often the first noticeable effects. Minimum commitment: 4 weeks.

Recommended vial
  • 10mg (only size)

At 500mcg/day, 10mg = 20 days ✓. Fits within shelf life perfectly.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Fully Reversible
Side effects

Limited data: mild GI discomfort (oral), injection site reaction (SubQ). Generally very well tolerated.

Interactions

NSAIDs (additive anti-inflammatory, may reduce need), immunosuppressives, biologics (additive)

Do not combine
KLOW Blend (BPC 10mg + TB 10mg + GHK-Cu 50mg + KPV 10mg)KLOW Blend (BPC 10mg + TB 10mg + GHK-Cu 50mg + KPV 10mg)

Handle with research caution

No strict contraindications with other peptides on this list.

Storage & handling

Lyophilised
12–24 months
room temp
Reconstituted
4–6 weeks
2–8°C

Videos & talks

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