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Healing repairImmuneIn StockSubQ injection

KPV

Tripeptide · Alpha-MSH C-terminal fragment · 3 amino acids

Half-life

~1-2h

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

room temp

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Anti-inflammatory tripeptide derived from alpha-MSH. Blocks NF-kB pathway, reduces TNF-alpha and IL-6. Particularly beneficial for gut inflammation (IBD, colitis), skin inflammation, and general immune modulation. No tanning effect (unlike full alpha-MSH).

Mechanism of Action

Tripeptide derived from alpha-MSH — potent anti-inflammatory. Downregulates NF-κB pathway. Used for gut inflammation (IBD/IBS), skin inflammation.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No pharmaceutical brand Research peptide only Derived from alpha-MSH fragment

Typical Research Dosage

200-500mcg/day SubQ or oral. Some protocols use up to 1mg/day for active gut inflammation.

Vial Duration Guide

10mg vial at 500mcg/day = 20 days.

Recommended Vial Size

★ 10mg (only size) At 500mcg/day, 10mg = 20 days ✓. Fits within shelf life perfectly.

Time to Effects

EARLY: 1-2 weeks FULL: 4-8 weeks Week 1-2: Anti-inflammatory effects beginning. If used for gut issues (IBD, IBS), may notice reduced bloating, discomfort, and improved digestion. Week 2-4: Significant inflammation reduction. Gut barrier function improving. Skin inflammation (if present) improving. Week 4-8: Full anti-inflammatory benefit. Gut healing substantial. Skin conditions improved. Gut-related improvements are often the first noticeable effects. Minimum commitment: 4 weeks.

Contraindications & Do Not Combine

No strict contraindications with other peptides on this list.

Common Side Effects

Limited data: mild GI discomfort (oral), injection site reaction (SubQ). Generally very well tolerated.

Drug Interactions

NSAIDs (additive anti-inflammatory, may reduce need), immunosuppressives, biologics (additive)

Reversibility

Fully reversible — anti-inflammatory modulation

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Brzoska et al. (1999) FEBS Lett 461:137-42 — Anti-inflammatory tripeptide from alpha-MSH • Kannengiesser et al. (2008) PLoS One 3:e3624 — Colitis model • Derived from C-terminal of alpha-MSH • NOT FDA APPROVED • Primarily preclinical data (gut inflammation models)

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Capsules: room temp. Reconstituted: 2-8°C, 14-21 days.

State	Condition	Duration
Lyophilised (sealed)	room temp	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

KPV discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$70.00 per vial

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Quick Reference

Half-life	~Hours (estimated — limited PK data)
Delivery	SubQ injection
Typical dose	200-500mcg/day
Storage (lyoph.)	room temp
Storage (recon.)	4–6 weeks
Endogenous?	Natural/Topping Up
Suppression	None known
WADA	Not listed
FDA status	Preclinical only