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Healing repairImmuneIn StockSubQ injection

LL-37

Cathelicidin peptide · 37 amino acids · Human-derived sequence

Half-life

~30min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

3–4 weeks

Refrigerate at 2-8C

Known For

Antimicrobial peptide. Part of the innate immune system. Kills bacteria, viruses, and fungi. Also promotes wound healing and modulates immune response. Being studied for infection-resistant wound healing.

Mechanism of Action

Human cathelicidin antimicrobial peptide. Part of innate immune system — kills bacteria, fungi, viruses. Also modulates inflammation and promotes wound healing.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No pharmaceutical brand Also known as: Cathelicidin Research peptide only

Typical Research Dosage

50-100mcg/day SubQ. Some protocols use up to 200mcg/day for active infections.

Vial Duration Guide

5mg vial at 100mcg/day = 50 days. ⚠️ Exceeds shelf life at this dose.

Recommended Vial Size

★ 5mg (only size) At 100mcg/day = 50 days ⚠️. At 200mcg/day = 25 days ✓. Use higher dosing range to stay within shelf life.

Time to Effects

EARLY: 1-2 weeks FULL: 4-8 weeks Week 1-2: Antimicrobial effects begin. If used for chronic infections, may notice reduced symptoms. Week 2-4: Wound healing enhancement. Immune function improvement. Week 4-8: Chronic infection resolution. Biofilm disruption (if applicable). Used in defined courses rather than indefinitely. Minimum commitment: 4 weeks.

Contraindications & Do Not Combine

• Caution with immunosuppressant medications (LL-37 stimulates immune response — may counteract immunosuppression)

Common Side Effects

Injection site pain/redness, potential mast cell activation (histamine release — can cause itching/flushing), fever if dose too high

Drug Interactions

Immunosuppressive drugs may reduce effectiveness. Avoid with active autoimmune conditions (may flare).

Reversibility

Fully reversible — immune peptide, body produces its own

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Vandamme et al. (2012) Cell Immunol 280:22-35 — Antimicrobial peptide review • Fabisiak et al. (2016) J Physiol Pharmacol 67:159-72 — GI tract effects • NOT FDA APPROVED • Primarily in-vitro/animal antimicrobial studies • Endogenously produced as cathelicidin

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 7-14 days (less stable than many peptides)

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	3–4 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

LL-37 discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$100.00 per vial

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Quick Reference

Half-life	~30 minutes to hours (rapidly degraded by proteases)
Delivery	SubQ injection
Typical dose	50-100mcg/day
Storage (lyoph.)	2–8°C
Storage (recon.)	3–4 weeks
Endogenous?	Natural/Topping Up
Suppression	None known
WADA	Not listed
FDA status	Preclinical only