HealingImmune

LL-37

Cathelicidin peptide · 37 amino acids · Human-derived sequence

FDA · PRECLINICAL ONLY

Half-life

~30 minutes

Very short

minsdays

Route

SubQ injection

Evidence

Preclinical only

Risk

Standard

Overview

Known for

Antimicrobial peptide. Part of the innate immune system. Kills bacteria, viruses, and fungi. Also promotes wound healing and modulates immune response. Being studied for infection-resistant wound healing.

Mechanism

Human cathelicidin antimicrobial peptide. Part of innate immune system — kills bacteria, fungi, viruses. Also modulates inflammation and promotes wound healing.

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Secondary
Supply & nature
Natural / Topping UpNatural
FDA category
Preclinical only

Evidence & standing

Evidence base
Preclinical only
Risk level
Standard
Best studies
5 references
  • Vandamme et al. (2012) Cell Immunol 280:22-35 — Antimicrobial peptide review
  • Fabisiak et al. (2016) J Physiol Pharmacol 67:159-72 — GI tract effects
  • NOT FDA APPROVED
  • Primarily in-vitro/animal antimicrobial studies
  • Endogenously produced as cathelicidin

Dosage & protocol

Typical dose
50-100mcg/day
Research range
1–5 mg
Cycle
4 weeks on / 4 weeks off
Onset
10 days first effects
Full effect
42 days
Half-life
~30min
~30 minutes to hours (rapidly degraded by proteases)
Protocol

50-100mcg/day SubQ. Some protocols use up to 200mcg/day for active infections.

Time to effects

EARLY: 1-2 weeks

FULL: 4-8 weeks

Week 1-2: Antimicrobial effects begin. If used for chronic infections, may notice reduced symptoms.

Week 2-4: Wound healing enhancement. Immune function improvement.

Week 4-8: Chronic infection resolution. Biofilm disruption (if applicable).

Used in defined courses rather than indefinitely. Minimum commitment: 4 weeks.

Recommended vial
  • 5mg (only size)

At 100mcg/day = 50 days ⚠️. At 200mcg/day = 25 days ✓. Use higher dosing range to stay within shelf life.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Fully Reversible
Side effects

Injection site pain/redness, potential mast cell activation (histamine release — can cause itching/flushing), fever if dose too high

Interactions

Immunosuppressive drugs may reduce effectiveness. Avoid with active autoimmune conditions (may flare).

Handle with research caution

  • Caution with immunosuppressant medications (LL-37 stimulates immune response — may counteract immunosuppression)

Storage & handling

Lyophilised
12–24 months
2–8°C
Reconstituted
3–4 weeks
2–8°C

Videos & talks

Independent educational content from researchers, clinicians and science communicators — not affiliated with Pepnerd.

Educational resources only. Videos are independent third-party content. Pepnerd is not affiliated with these creators and does not endorse or make claims based on their content. All products are for in-vitro research.