5-Amino-1MQ

Half-life

~2.5 hours

Short

minsdays

Route

SubQ injection

Evidence

Preclinical only

Risk

Standard

Overview

Known for

NNMT (nicotinamide N-methyltransferase) inhibitor. Increases cellular energy metabolism and fat burning by boosting NAD+ levels in fat cells. Shrinks fat cells and may prevent new fat cell formation.

Mechanism

NNMT inhibitor — blocks enzyme (nicotinamide N-methyltransferase) that promotes fat storage. May increase NAD+ and boost metabolism.

Key facts

Format

Lyophilized powder

Mechanism targets

Classification

Secondary

Supply & nature

ExogenousExogenous

FDA category

Preclinical only

Evidence & standing

Evidence base

Preclinical only

Risk level

Standard

Best studies

4 references

Neelakantan et al. (2018) BBRC 502(2):349-355 — NNMT inhibition and fat metabolism
Preclinical data only — mouse obesity models
NO HUMAN CLINICAL TRIALS
Small molecule, not a peptide technically

Dosage & protocol

Typical dose

50-100mg/day

Research range

50–200 mg

Cycle

8 weeks on / 4 weeks off

Onset

21 days first effects

Full effect

70 days

Half-life

~2-3h

~2-3 hours (oral compound)

Protocol

50-100mg/day orally or SubQ. Some protocols use up to 150mg/day.

Time to effects

EARLY: 2-4 weeks

FULL: 8-12 weeks

Week 2-4: Subtle increase in energy and metabolic rate. Fat oxidation improvements.

Week 4-8: Body composition changes become noticeable, especially when combined with exercise.

Week 8-12: Cumulative metabolic benefits.

Best results when stacked with exercise and/or GLP-1 agonists. Standalone effects are mild.

Recommended vial

50mg vials

At 50-100mg/day, 5mg vials impractical. 50mg = 1 day per vial. Buy in bulk. No shelf life concern — used immediately.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility

Fully Reversible

Side effects

Limited data: GI discomfort, nausea (reported anecdotally). No systematic side effect profile established.

Interactions

Unknown — no drug interaction studies

Handle with research caution

No strict contraindications with other peptides on this list.

Storage & handling

Lyophilised

Room temp (capsule)

Reconstituted

4–6 weeks

2–8°C

Videos & talks

Independent educational content from researchers, clinicians and science communicators — not affiliated with Pepnerd.

Educational resources only. Videos are independent third-party content. Pepnerd is not affiliated with these creators and does not endorse or make claims based on their content. All products are for in-vitro research.