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Sermorelin Acetate

Peptide · GHRH(1–29) sequence · 29 amino acids

Half-life

~10-20min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

2–4 weeks

Refrigerate at 2-8C

Known For

GHRH analogue. One of the oldest and most studied GH secretagogues. Gentler than CJC-1295. FDA-approved for GH deficiency diagnosis. Good entry-level GH peptide with extensive safety data.

Mechanism of Action

First 29 amino acids of natural GHRH. Stimulates GH release naturally. Clean profile BUT very short half-life limits effectiveness compared to CJC-1295.

Body vs. External Supply

🟢 Secretagogue (stimulates natural)

Brand / Trade Names

Geref® (formerly FDA-approved) Discontinued by manufacturer (Not for safety reasons — commercial decision)

Typical Research Dosage

100-300mcg before bed SubQ. Some protocols use 200mcg 2x daily.

Vial Duration Guide

5mg vial at 300mcg/day = ~17 days.

Recommended Vial Size

★ 5mg vials At 300mcg/day, 5mg = ~17 days ✓. Sermorelin is LESS stable (2-4 wk shelf life) so 5mg is ideal. 10mg risks degradation.

Time to Effects

EARLY: 2-4 weeks FULL: 12-16 weeks Gentler onset than CJC-1295. The 'slow burn' GH peptide. Week 2-4: Improved sleep quality. Week 4-8: Subtle recovery and energy improvements. Week 12-16: Cumulative anti-aging benefits. Slower and milder than CJC-1295. Minimum commitment: 12 weeks. Best for conservative, long-term GH optimisation.

Contraindications & Do Not Combine

• Do NOT combine with exogenous HGH • Do NOT combine with CJC-1295 (same GHRH receptor — use one or the other)

Common Side Effects

Flushing, headache, injection site pain/swelling (10-15%), dizziness, transient hyperactivity in children

Drug Interactions

Glucocorticoids (↓response), somatostatin analogs, thyroid hormones, insulin

Reversibility

🟢 Fully reversible — cleanest secretagogue profile

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Walker et al. (1990) JCEM 71:540-6 — GH response in adults • Vittone et al. (1997) Metabolism 46:89-96 — Elderly GH deficiency • Previously FDA APPROVED (Geref, 1997) — discontinued by manufacturer (not safety related) • Best-studied GH secretagogue for clinical use

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 14 days

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	2–4 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

Sermorelin Acetate discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$75.00 per vial

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Quick Reference

Half-life	~10-20 minutes (very short — limits efficacy)
Delivery	SubQ injection
Typical dose	100-300mcg
Storage (lyoph.)	2–8°C
Storage (recon.)	2–4 weeks
Endogenous?	Secretagogue (stimulates natural)
Suppression	None (stimulates GH)
WADA	Prohibited (S2)
FDA status	Approved (Geref — discontinued)