Melatonin (Injectable)

Indoleamine · Pineal neurohormone · Synthetic

Half-life

~40-60min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

room temp, per product label

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Sleep hormone. Injectable form provides more precise dosing and faster onset than oral. Regulates circadian rhythm, has antioxidant properties, and supports immune function. Injectable bypasses first-pass liver metabolism.

Mechanism of Action

Natural sleep hormone produced by pineal gland. Injectable bypasses poor oral bioavailability for stronger/faster effect. Antioxidant, immune modulation, circadian regulation.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No brand for injectable form Oral brands (widely available OTC): Natrol®, NOW Foods®, Life Extension® Prescription in Australia/EU

Typical Research Dosage

0.5-3mg SubQ 30 min before bed. Start low — injectable is more potent than oral due to 100% bioavailability.

Vial Duration Guide

10mg vial at 1mg/night = 10 days. At 3mg/night = ~3 days.

Recommended Vial Size

★ 10mg (only size) At 1mg/night = 10 days ✓. At 3mg/night = ~3 days ✓. No shelf life issues.

Time to Effects

EARLY: 30-60 minutes FULL: Single dose On-demand sleep aid. 30-60 min: Drowsiness onset. Sleep induction. Effects are per-dose. Injectable hits faster and harder than oral due to 100% bioavailability. No loading or accumulation needed. For circadian rhythm resetting: consistent timing for 1-2 weeks establishes the new pattern.

Contraindications & Do Not Combine

• Caution with sedatives, benzodiazepines, or other sleep aids (compounded sedation) • Caution with blood thinners (melatonin has mild anticoagulant properties)

Common Side Effects

Drowsiness (intended), vivid dreams, morning grogginess (dose too high or timed wrong), headache (rare)

Drug Interactions

Sedatives/hypnotics (additive), blood thinners (melatonin has mild anticoagulant effect), immunosuppressants (melatonin is immunomodulatory), CYP1A2 substrates

Reversibility

🟡 Fully reversible — supplementing natural hormone. No known suppression of endogenous production at normal doses.

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Claustrat et al. (2005) Sleep Med Rev 9:11-24 — Comprehensive review • Oral melatonin: Schedule 4 (prescription-only) in Australia for most formulations. Circadin 2mg is Schedule 3 (pharmacist-only) for adults 55+. • Injectable form has minimal published human data • Oral melatonin NOT FDA APPROVED as drug but regulated as dietary supplement • Injectable bypasses first-pass metabolism — faster onset

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Oral: room temp, per product label. Injectable reconstituted: 2-8°C, 14-21 days.

State	Condition	Duration
Lyophilised (sealed)	room temp, per product label	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Select Vial Size

$70.00 per vial

Submit Your Test Results →

Quick Reference

Half-life	~40-60 minutes (oral) \| ~20-30 minutes (injectable — faster clearance)
Delivery	SubQ injection
Typical dose	0.5-3mg
Storage (lyoph.)	room temp, per product label
Storage (recon.)	4–6 weeks
Endogenous?	Natural/Topping Up
Suppression	Mild endogenous suppression
WADA	Not listed
FDA status	OTC supplement (oral)