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DSIP (Delta Sleep-Inducing Peptide)

Nonapeptide · 9 amino acids · Neuropeptide

Half-life

~7-8min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

3–4 weeks

Refrigerate at 2-8C

Known For

Sleep peptide. Promotes delta wave (deep) sleep. May normalise disturbed sleep patterns rather than sedate. Also has stress-protective and analgesic properties. Works on sleep architecture rather than just inducing unconsciousness.

Mechanism of Action

Neuropeptide that promotes delta wave (deep) sleep. Also has stress-protective, pain-modulating, and hormone-normalizing properties.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No pharmaceutical brand Research peptide only Never commercialised

Typical Research Dosage

50-100mcg SubQ or intranasal before bed. Some use up to 250mcg.

Vial Duration Guide

5mg vial at 100mcg/night = 50 days. ⚠️ Exceeds shelf life.

Recommended Vial Size

★ 5mg vials At 100mcg/night = 50 days ⚠️ exceeds 3-4 wk shelf life. At 250mcg/night = 20 days ✓. Use higher dosing. 10mg = much worse.

Time to Effects

EARLY: 1-3 nights FULL: 2-4 weeks Night 1-3: Improved sleep onset and depth. Many notice better sleep quality from the first dose. Week 1-2: Normalised sleep architecture. More consistent deep sleep. Less nighttime waking. Week 2-4: Cumulative effects — improved daytime energy from better sleep. Stress recovery improved. Effects on sleep are felt quickly. Unlike sedatives, DSIP improves sleep QUALITY rather than just knocking you out. Minimum commitment: 2 weeks.

Contraindications & Do Not Combine

• Caution combining with other sedatives, benzodiazepines, or opioids (compounded CNS depression)

Common Side Effects

Headache, dizziness, mild sedation, vivid dreams. Limited safety data.

Drug Interactions

Sedatives, benzodiazepines, opioids (additive CNS depression), alcohol

Reversibility

Fully reversible — no known physical dependence

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Schoenenberger & Monnier (1977) PNAS 74:1282-6 — Original discovery • Kovalzon & Strekalova (2006) Peptides 27:2738-52 — Review • Naturally occurring in human blood and brain tissue • NOT FDA APPROVED • Mixed clinical results — some studies show sleep benefit, others equivocal

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 14 days (less stable than some peptides)

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	3–4 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

DSIP (Delta Sleep-Inducing Peptide) discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

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$45.00 per vial

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Quick Reference

Half-life	~7-8 minutes (very short)
Delivery	SubQ injection
Typical dose	50-100mcg
Storage (lyoph.)	2–8°C
Storage (recon.)	3–4 weeks
Endogenous?	Natural/Topping Up
Suppression	None known
WADA	Not listed
FDA status	Preclinical only