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ImmuneIn StockSubQ injection

VIP (Vasoactive Intestinal Peptide)

Neuropeptide · 28 amino acids · Gut-derived sequence

Half-life

~1-2min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

2–4 weeks

Refrigerate at 2-8C

Known For

Neuropeptide with broad anti-inflammatory, vasodilatory, and immune-modulating effects. Used in CIRS (Chronic Inflammatory Response Syndrome) and mould illness protocols. Regulates circadian rhythm, protects neurons, and supports gut function.

Mechanism of Action

Neuropeptide with broad effects: vasodilation, smooth muscle relaxation, immune regulation, gut motility, bronchodilation. Used in CIRS/mould illness protocols.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No pharmaceutical brand Available through compounding pharmacies Used in Shoemaker CIRS protocol

Typical Research Dosage

50-200mcg intranasal or SubQ daily. Dr. Shoemaker's CIRS protocol: 50mcg nasal spray 4x daily.

Vial Duration Guide

10mg vial at 200mcg/day = 50 days. ⚠️ Exceeds shelf life.

Recommended Vial Size

⚠️ 10mg (only size) — USE QUICKLY At 200mcg/day = 50 days ⚠️. VIP is very fragile (2-4 wk shelf life). Use 400-500mcg/day to finish in 3 weeks, or accept significant potency loss.

Time to Effects

EARLY: 1-2 weeks FULL: 4-12 weeks Week 1-2: If used for CIRS/mould illness — reduced brain fog, improved energy. Circadian rhythm normalising. Week 2-4: Significant symptom improvement in CIRS patients. Reduced inflammation. Week 4-12: Full symptom resolution in responsive patients. Effects are most dramatic in CIRS patients where VIP deficiency is the issue. Healthy individuals may notice less dramatic improvements. Minimum commitment: 4 weeks.

Contraindications & Do Not Combine

• Caution with blood pressure medications (VIP is a vasodilator — may compound hypotension)

Common Side Effects

Diarrhoea (vasodilation → gut hypermotility), flushing, hypotension (dose-dependent), nasal congestion

Drug Interactions

Antihypertensives (additive hypotension), vasodilators (additive), bronchodilators (additive)

Reversibility

Fully reversible — very short-acting

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Said & Mutt (1970) Science 169:1217-8 — Original discovery • Morice et al. (1983) Lancet 2:1225-7 — Asthma/bronchodilation • Prasse et al. (2010) PLoS One 5:e11934 — Sarcoidosis pilot • Extensive basic science literature (>10,000 PubMed citations) • NOT FDA APPROVED as therapeutic • Very fragile peptide — rapid degradation

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 14 days. Very sensitive to degradation.

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	2–4 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

VIP (Vasoactive Intestinal Peptide) discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

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$190.00 per vial

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Quick Reference

Half-life	~1-2 minutes (extremely short — limits SubQ utility)
Delivery	SubQ injection
Typical dose	50-200mcg
Storage (lyoph.)	2–8°C
Storage (recon.)	2–4 weeks
Endogenous?	Natural/Topping Up
Suppression	None known
WADA	Not listed
FDA status	Approved (Aviptadil — COVID)