Growth

PEG-MGF

PEGylated peptide · IGF-1 splice variant · Extended half-life

FDA · CATEGORY 2 (2023)

Half-life

~2.5 days

Long

minsdays

Route

SubQ injection

Evidence

Preclinical only

Risk

Standard

Overview

Known for

PEGylated version of MGF. The PEG attachment extends the half-life from minutes to hours. Better bioavailability and more practical dosing than standard MGF. Promotes muscle satellite cell activation.

Mechanism

PEGylated version of MGF — PEG chain extends half-life from minutes to hours/days. Allows systemic distribution and satellite cell activation.

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Secondary
Supply & nature
ExogenousExogenous
FDA category
Category 2 (2023)

Evidence & standing

Evidence base
Preclinical only
Risk level
Standard
Best studies
4 references
  • Same research base as MGF with PEGylation for extended half-life
  • Very limited published research
  • NOT FDA APPROVED
  • No human clinical trials

Dosage & protocol

Typical dose
200mcg
Research range
100–200 µg
Cycle
4 weeks on / 4 weeks off
Onset
21 days first effects
Full effect
49 days
Half-life
~48-72h
PEGylation extends native MGF half-life from ~5-7 min to ~48-72h in experimental models
Protocol

200mcg IM 2-3x per week. Inject into target muscle groups. Some use SubQ systemically.

Time to effects

EARLY: 2-4 weeks

FULL: 6-8 weeks

More reliable than standard MGF due to extended half-life.

Week 2-4: Improved muscle recovery in target areas.

Week 6-8: Enhanced repair and growth in trained muscles.

Minimum commitment: 6 weeks. Works best as part of a broader GH/recovery stack.

Recommended vial
  • 2mg (only size)

At 200mcg 3x/wk = ~3.3 weeks ✓. Fits within shelf life.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Fully Reversible
Side effects

Injection site reactions, flu-like symptoms (reported), limited safety data

Interactions

Unknown — very limited research

Do not combine
MGF (Mechano Growth Factor)MGF (Mechano Growth Factor)

Handle with research caution

  • Do NOT inject on same day as IGF-1 LR3 (alternate days)
  • Do NOT combine with standard MGF (pick one version)

Storage & handling

Lyophilised
12–24 months
2–8°C
Reconstituted
3–4 weeks
2–8°C