Hexarelin

Half-life

~1 hours

Short

minsdays

Route

SubQ injection

Evidence

Preclinical only

Risk

Moderate

Overview

Known for

The STRONGEST growth hormone releasing peptide. Most potent GH release of all GHRPs. Also has cardioprotective properties. But significantly increases cortisol and prolactin. Desensitises quickly (4-6 weeks).

Mechanism

Most potent GHRP for GH release. Also has direct cardiac protective effects (independent of GH). BUT raises cortisol/prolactin and desensitizes quickly.

Key facts

Format

Lyophilized powder

Mechanism targets

Classification

Secondary

Supply & nature

SecretagogueSecretagogue

FDA category

Category 2 (2023)

Evidence & standing

Evidence base

Preclinical only

Risk level

Moderate

Best studies

5 references

Ghigo et al. (1994) JCEM 78(3):693-8 — Potent GH release characterization
Deghenghi et al. (1994) Life Sci 54:1321-28
NOT FDA APPROVED
Known for desensitization after 4-6 weeks continuous use
Significant prolactin elevation documented

Dosage & protocol

Typical dose

100-200mcg

Research range

100–200 µg

Cycle

4 weeks on / 4 weeks off

Onset

10 days first effects

Full effect

35 days

Half-life

~1h

~1 hour

Protocol

100-200mcg per injection, 1-2x daily. Lower doses than other GHRPs due to potency.

Time to effects

EARLY: 1-2 weeks

FULL: 4-6 weeks (then desensitisation)

Week 1: Strong GH pulse felt — tingling, flushing, hunger. More noticeable than milder GHRPs.

Week 2-4: Rapid improvements in recovery and body composition. Strongest GHRP effect.

Week 4-6: ⚠️ Desensitisation begins. Effects plateau and diminish. Must cycle off for 4+ weeks.

This is a sprint, not a marathon. Use for 4-6 week bursts then switch to Ipamorelin or take a break.

Recommended vial

2mg vials

At 200mcg/day, 2mg = 10 days ✓. Must cycle 4 wks on/off — smaller vials align with cycles. 10mg = 50 days ⚠️ exceeds shelf life AND cycle length.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility

Fully Reversible

Side effects

Cortisol elevation (significant), prolactin elevation (significant), hunger, flushing, water retention, numbness/tingling

Interactions

Somatostatin analogs, dopamine agonists

Do not combine

CJC-1295 NO DAC 5mg + Ipamorelin 5mg (Blend)

Handle with research caution

Do NOT combine with exogenous HGH
Do NOT combine with other GHRPs (GHRP-2, GHRP-6) — Hexarelin is already the strongest, stacking = excessive cortisol/prolactin
Monitor prolactin levels — may require management

Storage & handling

Lyophilised

12–24 months

2–8°C

Reconstituted

4–6 weeks

2–8°C

Videos & talks

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