Dermorphin

Heptapeptide · Opioid receptor ligand · Amphibian-derived sequence

Half-life

~2-4h

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Extremely potent opioid peptide (40x more potent than morphine). Originally found in South American frogs. Highly selective mu-opioid receptor agonist. Used in pain research.

Mechanism of Action

⚠️ Potent mu-opioid receptor agonist — 30-40x more potent than morphine. Naturally found in South American frog skin. NOT developed for human medicine.

Body vs. External Supply

🔴 Exogenous (replaces natural)

Brand / Trade Names

No pharmaceutical brand ⚠️ Not developed for human use Known from horse racing scandals Illegal in equine sport

Typical Research Dosage

⚠️ Extremely potent. Microgram-level dosing. No established safe human protocol.

Vial Duration Guide

5mg vial contains many doses at microgram-level dosing.

Recommended Vial Size

⚠️ 5mg (only size) Microgram dosing = many doses. Will exceed shelf life. ⚠️ Potent opioid — extreme caution.

Time to Effects

EARLY: Minutes FULL: Single dose ⚠️ POTENT OPIOID. Effects within minutes of injection. Pain relief, euphoria, sedation. This is an acute-acting compound, not a protocol. Effects last hours per dose. HIGH RISK of dependence and overdose.

Contraindications & Do Not Combine

• ⚠️ Do NOT combine with ANY other opioid, sedative, benzodiazepine, or CNS depressant (fatal respiratory depression risk) • Do NOT combine with DSIP (compounded CNS depression)

Common Side Effects

⚠️ Full opioid side effect profile: respiratory depression (POTENTIALLY FATAL), sedation, nausea/vomiting, constipation, euphoria, physical dependence, tolerance

Drug Interactions

ALL CNS depressants (POTENTIALLY FATAL): benzodiazepines, alcohol, other opioids, sedatives, antihistamines. Naloxone reverses effects (emergency).

Reversibility

⚠️ ADDICTIVE — mu-opioid agonist. Physical dependence develops with repeated use. Withdrawal symptoms expected.

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Montecucchi et al. (1981) Int J Pept Protein Res 17:316-21 — Discovery (frog skin) • ~40x more potent than morphine • NOT FDA APPROVED • ILLEGAL in equine racing • ⚠️ POTENT OPIOID — extreme addiction/overdose risk • No therapeutic human development

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Select Vial Size

$40.00 per vial

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Quick Reference

Half-life	~2-4 hours
Delivery	SubQ injection
Typical dose	0.1-1mcg/kg
Storage (lyoph.)	2–8°C
Storage (recon.)	4–6 weeks
Endogenous?	Exogenous (replaces natural)
Suppression	None known
WADA	Prohibited (S0)
FDA status	Not approved