Home / Catalogue/ Healing repair/ TB-500 (Thymosin Beta-4 Acetate)

Healing repairIn StockSubQ injection

TB-500 (Thymosin Beta-4 Acetate)

Tetradecapeptide · Actin-binding sequence · 43 amino acids

Half-life

~4-6h

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

3–4 weeks

Refrigerate at 2-8C

Known For

Systemic healing peptide. Promotes cell migration, new blood vessel formation, and reduces inflammation throughout the body. Aids in wound healing, muscle repair, flexibility, and hair regrowth.

Mechanism of Action

Synthetic version of thymosin beta-4 — naturally occurring protein that promotes wound healing, cell migration, angiogenesis, and reduces inflammation.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

RegeneRx was developing as RGN-352 (cardiac) and RGN-259 (ophthalmic) No commercial brand reached market Research peptide only

Typical Research Dosage

Loading: 750mcg-2mg twice weekly for 4-6 weeks. Maintenance: 500mcg-1mg weekly. SubQ.

Vial Duration Guide

2mg vial at 1mg 2x/wk = 1 week (loading). 5mg = 2.5 weeks. 10mg = 5 weeks.

Recommended Vial Size

★ 5mg vials Loading at 2mg/wk, 5mg = 2.5 weeks ✓. 10mg at loading = 5 weeks ✓. Maintenance (500mcg-1mg/wk): use 2mg vials.

Time to Effects

EARLY: 1-2 weeks FULL: 4-8 weeks Week 1-2: Reduced inflammation, improved flexibility. Some report a 'loosening' of tight/scarred tissue. Week 2-4: Systemic healing effects. Improved recovery between training sessions. Hair regrowth may begin in some individuals. Week 4-8: Significant healing of chronic injuries. Flexibility improvements. Visible wound healing enhancement. Loading phase (higher dose for first 4-6 weeks) is important — don't start at maintenance. Minimum commitment: 6 weeks.

Contraindications & Do Not Combine

• Same angiogenesis concern as BPC-157 — avoid if active cancer/tumour history

Common Side Effects

Limited data: headache, lethargy, flu-like symptoms initially (reported). Malinda 1999 animal data: well-tolerated.

Drug Interactions

Unknown — no drug interaction studies

Reversibility

Fully reversible — supports natural healing processes

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Malinda et al. (1999) J Invest Dermatol 113(3):364-8 — Wound healing in rats (42-61% improvement) • Kleinman & Sosne (2016) Vitam Horm 102:251-75 — Dermal healing review (Phase 2 stasis/pressure ulcers) • Sosne et al. (2002) Exp Eye Res 74:293-9 — Corneal wound healing • Bock-Marquette et al. (2004) Nature 432:466-72 — Cardiac repair • ClinicalTrials.gov: NCT00832091 (venous stasis ulcers) • NOT FDA APPROVED • Phase 2 dermal/corneal trials showed accelerated healing by ~1 month

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 14-21 days

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	3–4 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

TB-500 (Thymosin Beta-4 Acetate) discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

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$45.00 per vial

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Quick Reference

Half-life	~4-6 hours (estimated)
Delivery	SubQ injection
Typical dose	750mcg
Storage (lyoph.)	2–8°C
Storage (recon.)	3–4 weeks
Endogenous?	Natural/Topping Up
Suppression	None
WADA	Prohibited (S0)
FDA status	Category 2 (2023)