SexSkin

Melanotan 2

Cyclic heptapeptide · Alpha-MSH analogue · 7 amino acids

FDA · NOT APPROVED

Half-life

~1 hours

Short

minsdays

Route

SubQ injection

Evidence

Preclinical only

Risk

Elevated

Overview

Known for

Synthetic analogue of alpha-MSH. Causes skin tanning without UV exposure, increases libido, and suppresses appetite. Also promotes fat loss. Side effects include nausea, facial flushing, and darkening of moles.

Mechanism

Non-selective melanocortin agonist — stimulates melanin production (tanning), sexual arousal, appetite suppression. ⚠️ Multiple off-target effects due to non-selectivity.

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Secondary
Supply & nature
ExogenousExogenous
FDA category
Not approved

Evidence & standing

Evidence base
Preclinical only
Risk level
Elevated
Best studies
5 references
  • Dorr et al. (1996) Life Sci 58:1777-84 — Human tanning response
  • Wessells et al. (2000) Int J Impot Res 12:S74-79 — Sexual function effects
  • NOT FDA APPROVED
  • ⚠️ Associated with melanoma risk — dermatology concern
  • PT-141 was derived from MT-2 research

Dosage & protocol

Typical dose
0.25-0.5mg/day
Research range
0.25–1 mg
Cycle
Loading then maintenance
Onset
5 days first effects
Full effect
21 days
Half-life
~1h
~1 hour
Protocol

Loading: 0.25-0.5mg/day SubQ for 2-3 weeks. Maintenance: 0.5-1mg every 3-7 days. Start low — nausea is common.

Time to effects

EARLY: 3-7 days

FULL: 2-4 weeks

Day 1-3: Nausea, facial flushing, possible erections (side effects felt almost immediately).

Day 3-7: Subtle darkening of skin, especially in areas that get sun exposure. Freckles/moles may darken first.

Week 1-2: Visible tan developing. Libido increase noticeable.

Week 2-4: Full tan achieved. Maintenance dosing to sustain.

One of the FASTEST acting peptides for visible results. Loading phase = 2-3 weeks. Some UV exposure accelerates results significantly.

Recommended vial
  • 10mg (only size)

Loading at 0.5mg/day = 20 days ✓. Maintenance 0.5mg every 3-7 days = 60-140 days ⚠️. Loading phase fits; maintenance won't.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Not Reversible
Side effects

Nausea (60-70%, especially initial doses), facial flushing (50%), spontaneous erections (men), fatigue, headache, ⚠️ NEW/CHANGED MOLES (requires dermatological monitoring)

Interactions

Blood pressure medications (MT2 can affect BP), PDE5 inhibitors like sildenafil (additive priapism risk in men)

Do not combine
Melanotan 1 (MT-1)Melanotan 1 (MT-1)

Handle with research caution

  • Do NOT combine with Melanotan 1 (same receptor — pick one)
  • Caution if history of melanoma or atypical moles (stimulates melanocyte activity)

Storage & handling

Lyophilised
12–24 months
2–8°C
Reconstituted
4–6 weeks
2–8°C

Videos & talks

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