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Melanotan 2

Cyclic heptapeptide · Alpha-MSH analogue · 7 amino acids

Half-life

~1h

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

4–6 weeks

Refrigerate at 2-8C

Known For

Synthetic analogue of alpha-MSH. Causes skin tanning without UV exposure, increases libido, and suppresses appetite. Also promotes fat loss. Side effects include nausea, facial flushing, and darkening of moles.

Mechanism of Action

Non-selective melanocortin agonist — stimulates melanin production (tanning), sexual arousal, appetite suppression. ⚠️ Multiple off-target effects due to non-selectivity.

Body vs. External Supply

🔴 Exogenous (replaces natural)

Brand / Trade Names

No pharmaceutical brand Research peptide only ⚠️ Not FDA approved anywhere Often sold illegally as 'Barbie Drug'

Typical Research Dosage

Loading: 0.25-0.5mg/day SubQ for 2-3 weeks. Maintenance: 0.5-1mg every 3-7 days. Start low — nausea is common.

Vial Duration Guide

10mg vial at 0.5mg loading dose = 20 days loading. Maintenance lasts months.

Recommended Vial Size

★ 10mg (only size) Loading at 0.5mg/day = 20 days ✓. Maintenance 0.5mg every 3-7 days = 60-140 days ⚠️. Loading phase fits; maintenance won't.

Time to Effects

EARLY: 3-7 days FULL: 2-4 weeks Day 1-3: Nausea, facial flushing, possible erections (side effects felt almost immediately). Day 3-7: Subtle darkening of skin, especially in areas that get sun exposure. Freckles/moles may darken first. Week 1-2: Visible tan developing. Libido increase noticeable. Week 2-4: Full tan achieved. Maintenance dosing to sustain. One of the FASTEST acting peptides for visible results. Loading phase = 2-3 weeks. Some UV exposure accelerates results significantly.

Contraindications & Do Not Combine

• Do NOT combine with Melanotan 1 (same receptor — pick one) • Caution if history of melanoma or atypical moles (stimulates melanocyte activity)

Common Side Effects

Nausea (60-70%, especially initial doses), facial flushing (50%), spontaneous erections (men), fatigue, headache, ⚠️ NEW/CHANGED MOLES (requires dermatological monitoring)

Drug Interactions

Blood pressure medications (MT2 can affect BP), PDE5 inhibitors like sildenafil (additive priapism risk in men)

Reversibility

Pigmentation changes: slow to reverse (weeks-months). Sexual effects: short-acting. Mole changes may be permanent.

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Dorr et al. (1996) Life Sci 58:1777-84 — Human tanning response • Wessells et al. (2000) Int J Impot Res 12:S74-79 — Sexual function effects • NOT FDA APPROVED • ⚠️ Associated with melanoma risk — dermatology concern • PT-141 was derived from MT-2 research

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 30 days (relatively stable)

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	4–6 weeks

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

Melanotan 2 discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

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Quick Reference

Half-life	~1 hour
Delivery	SubQ injection
Typical dose	0.25-0.5mg/day
Storage (lyoph.)	2–8°C
Storage (recon.)	4–6 weeks
Endogenous?	Exogenous (replaces natural)
Suppression	None known
WADA	Not listed
FDA status	Not approved