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Sexual healthIn StockSubQ injection

Kisspeptin-10

Decapeptide · GPR54 ligand · 10 amino acids

Half-life

~28min

After administration

Delivery Method

SubQ injection

Route of administration

Storage (Lyophilised)

12-24 months

2–8°C

Storage (Reconstituted)

7–14 days

Refrigerate at 2-8C

Known For

Fragment of kisspeptin that stimulates GnRH release from the hypothalamus. Increases LH and FSH, boosting natural testosterone and fertility. Used in fertility research and as a natural testosterone booster.

Mechanism of Action

Master regulator of reproductive axis — signals hypothalamus to release GnRH → LH/FSH → testosterone/estrogen. 'Upstream switch' for entire HPG axis.

Body vs. External Supply

🟡 Natural/Topping Up

Brand / Trade Names

No pharmaceutical brand Research peptide Multiple clinical trials ongoing (fertility)

Typical Research Dosage

50-100mcg SubQ 1-2x daily. Some fertility protocols use higher bolus doses.

Vial Duration Guide

5mg vial at 100mcg/day = 50 days. 10mg = 100 days. ⚠️ Exceeds shelf life.

Recommended Vial Size

★ 5mg vials At 100mcg/day, 5mg = 50 days ⚠️. 10mg = 100 days ⚠️ much worse. 5mg + higher dosing (200mcg/day = 25 days ✓) is ideal.

Time to Effects

EARLY: 2-4 weeks FULL: 8-12 weeks Week 1-2: LH/FSH increase measurable on blood work. Subtle energy/mood changes. Week 2-4: Testosterone increase (if baseline was suboptimal). Improved libido. Week 4-8: Fertility improvements measurable on semen analysis. Hormonal optimisation. Week 8-12: Full hormonal benefits. For fertility specifically: minimum 3 months (one full sperm cycle = 74 days). Blood work at 4 weeks to confirm LH/FSH response.

Contraindications & Do Not Combine

No strict contraindications with other peptides on this list.

Common Side Effects

Flushing, headache, mild GI discomfort (limited data)

Drug Interactions

GnRH analogs (may interact), hormonal contraceptives, anti-androgens

Reversibility

Fully reversible — stimulates natural axis. No suppression of endogenous production.

Key Peer-Reviewed References

All studies are published in indexed journals unless otherwise noted.

• Dhillo et al. (2005) JCEM 90:6609-15 — Stimulates gonadotropin release in humans • Jayasena et al. (2014) JCEM 99:E2762-9 — Pulsatile LH stimulation • ClinicalTrials.gov: Multiple ongoing fertility trials • NOT FDA APPROVED • Physiological GnRH pulse generator — upstream of GnRH

Research Disclaimer

Almost all data is preclinical (animal or in-vitro). No large-scale randomised controlled human trials are available for most compounds on this catalogue. This information is provided for research reference only.

Storage Requirements

Reconstituted: 2-8°C, 7-14 days (less stable)

State	Condition	Duration
Lyophilised (sealed)	2–8°C	12-24 months
Reconstituted	2-8C	7–14 days

Reconstitution Note

Reconstitute with bacteriostatic water (BAC water). Do not shake vigorously -- swirl gently to dissolve. Inject BAC water slowly down the side of the vial to avoid denaturing the peptide.

Video Resources

Kisspeptin-10 discussed by researchers & practitioners

Independent educational content from researchers, clinicians, and science communicators. Not affiliated with Pepnerd — provided as supplementary reading.

Educational resources only. The videos above are independent third-party content from researchers, clinicians, and science communicators. Pepnerd is not affiliated with any of these creators and does not endorse or make any claims based on their content. All products are sold strictly for in-vitro scientific research.

Select Vial Size

$70.00 per vial

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Quick Reference

Half-life	~28 minutes (very short)
Delivery	SubQ injection
Typical dose	50-100mcg
Storage (lyoph.)	2–8°C
Storage (recon.)	7–14 days
Endogenous?	Natural/Topping Up
Suppression	None (stimulates)
WADA	Not listed
FDA status	Investigational