Sex

Kisspeptin-10

Decapeptide · GPR54 ligand · 10 amino acids

FDA · INVESTIGATIONAL

Half-life

~28 minutes

Very short

minsdays

Route

SubQ injection

Evidence

Clinical trial data

Risk

Standard

Overview

Known for

Fragment of kisspeptin that stimulates GnRH release from the hypothalamus. Increases LH and FSH, boosting natural testosterone and fertility. Used in fertility research and as a natural testosterone booster.

Mechanism

Master regulator of reproductive axis — signals hypothalamus to release GnRH → LH/FSH → testosterone/estrogen. 'Upstream switch' for entire HPG axis.

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Active
Supply & nature
Natural / Topping UpNatural
FDA category
Investigational

Evidence & standing

Evidence base
Clinical trial data
Risk level
Standard
Clinical phase
Phase 2
Best studies
5 references
  • Dhillo et al. (2005) JCEM 90:6609-15 — Stimulates gonadotropin release in humans
  • Jayasena et al. (2014) JCEM 99:E2762-9 — Pulsatile LH stimulation
  • ClinicalTrials.gov: Multiple ongoing fertility trials
  • NOT FDA APPROVED
  • Physiological GnRH pulse generator — upstream of GnRH

Dosage & protocol

Typical dose
50-100mcg
Research range
1–3 nmol/kg
Cycle
Per protocol
Onset
21 days first effects
Full effect
70 days
Half-life
~28min
~28 minutes (very short)
Protocol

50-100mcg SubQ 1-2x daily. Some fertility protocols use higher bolus doses.

Time to effects

EARLY: 2-4 weeks

FULL: 8-12 weeks

Week 1-2: LH/FSH increase measurable on blood work. Subtle energy/mood changes.

Week 2-4: Testosterone increase (if baseline was suboptimal). Improved libido.

Week 4-8: Fertility improvements measurable on semen analysis. Hormonal optimisation.

Week 8-12: Full hormonal benefits.

For fertility specifically: minimum 3 months (one full sperm cycle = 74 days). Blood work at 4 weeks to confirm LH/FSH response.

Recommended vial
  • 5mg vials

At 100mcg/day, 5mg = 50 days ⚠️. 10mg = 100 days ⚠️ much worse. 5mg + higher dosing (200mcg/day = 25 days ✓) is ideal.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Fully Reversible
Side effects

Flushing, headache, mild GI discomfort (limited data)

Interactions

GnRH analogs (may interact), hormonal contraceptives, anti-androgens

Handle with research caution

No strict contraindications with other peptides on this list.

Storage & handling

Lyophilised
12–24 months
2–8°C
Reconstituted
7–14 days
2–8°C

Videos & talks

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