Sex

Gonadorelin Acetate

Decapeptide · GnRH sequence · 10 amino acids

FDA · APPROVED (FACTREL)

Half-life

~3 minutes

Very short

minsdays

Route

SubQ injection

Evidence

Approved therapeutic

Risk

Standard

Overview

Known for

Synthetic GnRH (gonadotropin-releasing hormone). Stimulates pituitary to release LH and FSH. Used to maintain or restore fertility and testicular function, especially during TRT. Also used diagnostically.

Mechanism

Identical to endogenous GnRH — signals pituitary to release LH and FSH. Used diagnostically (test pituitary function) and therapeutically (pulsatile for fertility).

Key facts

Format
Lyophilized powder
Mechanism targets
Classification
Caution
Supply & nature
SecretagogueSecretagogue
FDA category
Approved (Factrel)

Evidence & standing

Evidence base
Approved therapeutic
Risk level
Standard
Best studies
5 references
  • Previously FDA Approved as Factrel (1976) — diagnostic GnRH stimulation test
  • Lutrepulse (pulsatile) for hypothalamic amenorrhea — discontinued
  • Well-established pharmacology — identical to endogenous GnRH
  • Used in fertility clinics for decades
  • Common in TRT protocols to maintain testicular function

Dosage & protocol

Typical dose
100-400mcg
Research range
50–100 µg
Cycle
Pulsatile (every 90 min) or per protocol
Onset
21 days first effects
Full effect
70 days
Half-life
~2-4min
~2-4 minutes (IV) | ~20-40 minutes (SubQ)
Protocol

100-400mcg SubQ 2-3x per week. Some protocols use daily microdoses.

Time to effects

EARLY: 2-4 weeks

FULL: 8-12 weeks

Week 1-2: LH/FSH response measurable on blood work.

Week 2-4: Testosterone levels stabilising/increasing. Testicular volume maintained or improving.

Week 4-8: Hormonal improvements reflected in energy, libido, mood.

Week 8-12: Full effect. Fertility parameters improved.

For fertility: minimum 3 months. For testosterone support: 6-8 weeks to assess.

Recommended vial
  • 2mg (only size)

At 200mcg 3x/wk, 2mg = ~3.3 weeks ✓. Perfect shelf life fit.

Reference figures only

Dosing reflects published laboratory protocols and is not guidance for use in any living subject.

Safety

Reversibility
Fully Reversible
Side effects

Flushing, headache, nausea (mild), injection site reaction, allergic reaction (rare)

Interactions

GnRH agonists/antagonists (contraindicated — opposite effects), dopamine agonists, gonadal steroids affect response

Do not combine
HCG (Human Chorionic Gonadotropin)HCG (Human Chorionic Gonadotropin)

Handle with research caution

  • Caution combining with HCG (both stimulate LH pathway — monitor estrogen/testosterone ratio to avoid excess stimulation)

Storage & handling

Lyophilised
12–24 months
2–8°C
Reconstituted
2–4 weeks
2–8°C

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